Phase 1: Screening                                                                 April, 2006

The screening phase of the Natural History Study identifies people at increased risk for developing type 1 diabetes.

People who qualify and choose to participate in the Natural History Study may also be offered an opportunity to enter a diabetes prevention study in the future.

To be screened, you must fulfill at least one of the two conditions below:

1 to 45 years of age and have a brother, sister, child, or parent with type 1 diabetes

1 to 20 years of age and have a cousin, aunt, uncle, niece, nephew, half sibling, or grandparent with type 1 diabetes

What is the purpose of these screening tests?

The first screening test looks for autoantibodies associated with type 1 diabetes in your blood. Autoantibodies are proteins made by the immune system.

Autoantibodies are a sign that your immune system may be attacking the insulin- producing cells in your pancreas. Having these autoantibodies places you at greater risk for developing diabetes.

About 3 to 4 percent of family members of people with type 1 diabetes will have autoantibodies in their blood.

To do this screening test, a small sample of blood is drawn from your arm at a TrialNet clinic or you can ask us to send you a test kit that you can take to a local lab or your own doctor to have your blood drawn. Then the blood sample is sent to the TrialNet central laboratory for analysis.

In 4 to 6 weeks, you will learn your test results.

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